Statham began as a crossroads with a country store and post office, owned by M. J. C. Statham, but experienced growth, and incorporation, when the railroad came to town in 1892. The first depot was built around 1900 and was replaced with this structure in 1912. Though use of the depot was discontinued decades ago, it has been home to various businesses over the years.

Statham Historic District, National Register of Historic Places