At his wife’s suggestion, Dr. Orlando L. Alexander (1852-1920) built this hotel, where the couple kept a residence, as well. Dr. Alexander was a local physician who received his medical schooling at the Johns Hopkins University in Baltimore. He served on a statewide medical conference in 1905. The hotel was built by D. J. Nobles, a master carpenter from Hagan, Georgia, who was responsible for as many as 25 structures in the general area; it was the first location in Tattnall County to have electricity and the first to have telephone service.
National Register of Historic Places
Vanishing Georgia: Photographs by Brian Brown 
This is an excellent picture of the Alexander Hotel. The north wing of the hotel was added to the original structure in – I think – the late teens of the 20th century. There are pictures of the building before the addition.