A review of available sources, including The Architecture of Middle Georgia: The Oconee Area and The History of Baldwin County, date this house to circa 1850. (A sign on the property dates it to 1820*). The first name associated with the house is that of Fleming Grantland DuBignon. Mr. DuBignon was a grandson of Seaton Grantland, founder of the Milledgeville Recorder newspaper (which survives today as the Union-Recorder) and longtime owner of Woodville Plantation, and a great-grandson of early Jekyll Island settler and French immigrant Christophe Poulain DuBignon (du Bignon).
Later owners included the Brown, Moore, Arcangeli, and Sisson families.
*-It’s possible that further research has determined the 1820 date, but I am unaware of it.
Milledgeville Historic District, National Register of Historic Places